Young Boys welcome Manchester United to Stadion Wankdorf, Bern, Switzerland in the opening Group F encounter.
With Villarreal and Atalanta not in action until later on Tuesday evening, victory for either Young Boys or Man Utd could put them top for at least two hours.
Young Boys have no fresh injury concerns to report after thrashing Zurich 4-0 on Saturday.
Fabian Lustenberger, Jean-Pierre Nsame (both Achilles), Joel Monteiro, Esteban Petignat (both knee) and Nico Maier (muscle) are ruled out.
Man Utd will be without Edinson Cavani as he continues to build his match fitness, following a minor knock.
Dean Henderson, Phil Jones (both fitness), Alex Telles (ankle), Scott McTominay (groin), Amad Diallo (thigh) and Marcus Rashford (shoulder) remain absent.
- Young Boys are winless in two previous meetings against Manchester United in Champions League (L2).
- Man Utd won their only previous away trip to Young Boys in September 2018, winning 3-0 with a brace from Paul Pogba and a strike from Anthony Martial.
- Young Boys have won just one of four home matches against English opposition in all UEFA competitions (W1, L3), whilst also scoring in three of those four home clashes.
- Utd have lost two of four previous away trips to Swiss opposition in all UEFA competitions, although three of those clashes were against Basel.
- This is the first match involving Young Boys and Man Utd to be refereed by Francois Letexier.
Young Boys have been very consistent in the Swiss Super League this season under ex Huddersfield manager, David Wagner, which should mean that they won’t be expected pushovers unlike their last meeting here three years ago despite keeping one clean sheet in Qualifying this season in this competition.
Man Utd meanwhile looked fantastic in their defending and movement on the ball with a strong energy and clinical finishing against Newcastle on Saturday, of which I can’t see them letting slip here if can get on the front foot quickly.
Prediction: Young Boys 0-3 Manchester United
Result: Young Boys 2-1 Manchester United